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Results for "

Ca2 concentration

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (4) Autophagy (4) Bacterial (4) Biochemical Assay Reagents (2) Calcium Channel (8) Calmodulin (2) CaSR (2) CCR (1) Fluorescent Dye (3) Fungal (3) G protein-coupled Bile Acid Receptor 1 (1) Isotope-Labeled Compounds (1) mAChR (1) Microtubule/Tubulin (1) Na+/K+ ATPase (1) Oxidative Phosphorylation (3) Parasite (1) Phosphatase (1) PKA (1) Potassium Channel (1) Reactive Oxygen Species (2) Thyroid Hormone Receptor (2) TRP Channel (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Endocrinology (3) Infection (5) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (13)

By Targets:

Antibiotic (2)

Apoptosis (4)

Autophagy (4)

Bacterial (4)

Biochemical Assay Reagents (2)

Calcium Channel (8)

Calmodulin (2)

CaSR (2)

CCR (1)

Fluorescent Dye (3)

Fungal (3)

G protein-coupled Bile Acid Receptor 1 (1)

Isotope-Labeled Compounds (1)

mAChR (1)

Microtubule/Tubulin (1)

Na+/K+ ATPase (1)

Oxidative Phosphorylation (3)

Parasite (1)

Phosphatase (1)

PKA (1)

Potassium Channel (1)

Reactive Oxygen Species (2)

Thyroid Hormone Receptor (2)

TRP Channel (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (3)

Endocrinology (3)

Infection (5)

Inflammation/Immunology (4)

Metabolic Disease (4)

Neurological Disease (13)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: CRAC Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101396

ICA-069673 2 Publications Verification	Potassium Channel	Neurological Disease
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC₅₀s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells .

HY-N6789

KT5720 3 Publications Verification	PKA	Neurological Disease Cancer
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 ⁺ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases .

HY-B0596

Taltirelin TA-0910	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) .

HY-B0596A

Taltirelin acetate TA-0910 acetate	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) .

HY-156082

RyRs activator 3	Parasite Calcium Channel	Others
RyRs activator 3 (compound A4) is an effective insecticide against diamondback moths (M. separata) and diamondback moths (P. xylostella). The LC50 value of RyRs activator 3 against diamondback moth is 3.27 mg/L. RyRs activator 3 can bind to ryanodine receptor, increase cytoplasmic Ca2+ concentration, and produce biological toxicity .

HY-113970A

Nebracetam hydrochloride WEB 1881 FU hydrochloride	mAChR	Neurological Disease
Nebracetam hydrochloride, a nootropic M₁-muscarinic agonist, induces a rise of intracellular Ca ²⁺ concentration. Nebracetam hydrochloride exhibits an EC₅₀ of 1.59 mM for elevating [Ca ²⁺]_i .

HY-D1024

Coelenterazine h 2 Publications Verification 2-Deoxycoelenterazine; CLZN-h	Calcium Channel Biochemical Assay Reagents	Neurological Disease
Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca ²⁺, thus providing a valuable tool for measuring small changes in Ca ²⁺ concentrations .

HY-D1024A

Coelenterazine h hydrochloride 2 Publications Verification 2-Deoxycoelenterazine hydrochloride; CLZN-h hydrochloride	Biochemical Assay Reagents Calcium Channel	Neurological Disease
Coelenterazine h (2-Deoxycoelenterazine) hydrochloride, a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h hydrochloride is more sensitive to Ca ²⁺, thus providing a valuable tool for measuring small changes in Ca ²⁺ concentrations .

HY-W010451

1,2,4-Trihydroxybenzene	Calcium Channel	Cardiovascular Disease
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca ²⁺ concentration in rat thymic lymphocytes .

HY-D1702

Mag-Fura-2 tetrapotassium	Fluorescent Dye	Others
Mag-Fura-2 tetrapotassium is a UV excitable rational fluorescent Mg ²⁺/Ca ²⁺ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg ²⁺ and Ca ²⁺ concentrations .

HY-D1700

Mag-indo-1/AM	Fluorescent Dye	Others
Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg ²⁺ and also for Ca ²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg ²⁺ and Ca ²⁺ concentrations .

HY-10171

NPS-2143 hydrochloride Maximum Cited Publications 15 Publications Verification SB-262470A hydrochloride	CaSR	Metabolic Disease
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-10007

NPS-2143 Maximum Cited Publications 15 Publications Verification SB-262470A	CaSR	Metabolic Disease
NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-117073

ITH12575	Calcium Channel	Neurological Disease
ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca ²⁺ influx through CALHM1 at low micromolar concentrations .

HY-D0202

Arsenazo III	Fluorescent Dye	Others
Arsenazo III is a dye useful for detection of micromolar concentrations of ionized Ca ²⁺. Arsenazo III can be used for determination of thorium, zirconium, uranium and rare earth elements .

HY-103306

Ryanodine	Others	Neurological Disease
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca ²⁺ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

HY-13103

NS 11021 1 Publications Verification
NS 11021 is a potent and specific Ca ²⁺-activated big-conductance K ⁺ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials .

HY-136190

TRPC6-PAM-C20	TRP Channel	Neurological Disease
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca ²⁺ concentrations ([Ca ²⁺]i) in TRPC6-expressing HEK293 cells with an EC₅₀ of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals .

HY-124416

ML604086	CCR	Inflammation/Immunology Endocrinology
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca ²⁺ concentrations .

HY-N11887

Linocinnamarin	Reactive Oxygen Species	Inflammation/Immunology
Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin has anti-inflammatory activity. Linocinnamarin inhibits antigen-stimulated elevation of intracellular free Ca ²⁺ concentration and reactive oxygen species (ROS) .

HY-P1076

CALP2	Calmodulin	Inflammation/Immunology
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages .

HY-B0596S

Taltirelin-13C,d3 TA-0910-¹³C,d₃	Isotope-Labeled Compounds	Neurological Disease
Taltirelin- ¹³C,d₃ (TA-0910- ¹³C,d₃) is ¹³C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release).

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .

HY-B1837A

β-Cyfluthrin beta-Cyfluthrin	Calcium Channel	Neurological Disease
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca ²⁺ ATPase involved in calcium transport .

HY-114252

Strophanthidin	Na+/K+ ATPase	Cardiovascular Disease
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 µmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-N2500

Deoxypodophyllotoxin	Microtubule/Tubulin Apoptosis Autophagy	Infection Cardiovascular Disease
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis . Deoxypodophyllotoxin induces cell autophagy and apoptosis . Deoxypodophyllotoxin evokes increase of intracellular Ca ²⁺ concentrations in DRG neurons .

HY-N6687

Calcimycin 5+ Cited Publications A-23187; Antibiotic A-23187	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-B1837AR

β-Cyfluthrin (Standard) beta-Cyfluthrin (Standard)	Calcium Channel	Neurological Disease
β-Cyfluthrin (Standard) is the analytical standard of β-Cyfluthrin. This product is intended for research and analytical applications. β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca ²⁺ ATPase involved in calcium transport .

HY-N6687B

Calcimycin hemimagnesium A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy	Infection Cancer
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis .

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemiCalcium salt; Antibiotic A-23187 hemiCalcium salt	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis .

HY-136409

N-Decanoyl-L-homoserine lactone C10-HSL	Bacterial Reactive Oxygen Species	Infection
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca ²⁺ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .

HY-11000A

CaMKP inhibitor sodium	Phosphatase	Cancer
CaMKP inhibitor sodium (compound 5) is an inhibitor of Ca ²⁺/neutral protein-dependent protein concentration (CaMKP) and its nuclear type (CaMKP-N) (IC50: 6.4 μM, CaMKP; 6.6 μM, CaMKP-N). CaMKP is one type of Ser/Thr protein, which can be passed through to remove the oxidized oxidized protein (CaMK). CaMKP inhibitor sodium inhibits CaMKP mediated phospho-CaMKI hydrolysis, unaffectes protein phosphoric acid 2C (PP2C) and calcineurin (CaN) .

HY-14229

TGR5 Receptor Agonist 1 Publications Verification CCDC	G protein-coupled Bile Acid Receptor 1 Calcium Channel	Metabolic Disease
TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC₅₀s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular *Ca ²⁺* concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library	1118 compounds
Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important. MCE designs a unique collection of 1118 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Ion Channel Compound Library

1118 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1118 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type